Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome

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Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome

Mitochondria preserve very complex and distinctively unique machinery to maintain and express the content of mitochondrial DNA (mtDNA). Similar to chromosomes, mtDNA is packaged into discrete mtDNA-protein complexes referred to as a nucleoid. In addition to its role as a mtDNA shield, over 50 nucleoid-associated proteins play roles in mtDNA maintenance and gene expression through either tempora...

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ژورنال

عنوان ژورنال: Oxidative Medicine and Cellular Longevity

سال: 2017

ISSN: 1942-0900,1942-0994

DOI: 10.1155/2017/8060949